5-AMINO-1MQ

5-Amino-1MQ – Research Use Only

Overview

5-Amino-1MQ is a small molecule compound studied for its inhibitory activity on nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular methylation balance and metabolic regulation. NNMT plays a significant role in nicotinamide metabolism and is associated with pathways influencing NAD+ availability and mitochondrial function.

This compound is commonly utilized in laboratory research investigating cellular energy regulation, metabolic signaling pathways, and adaptive metabolic responses.

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Background

Nicotinamide N-methyltransferase (NNMT) is an enzyme responsible for catalyzing the methylation of nicotinamide, which can influence intracellular NAD+ metabolism and methyl donor utilization. Altered NNMT activity has been studied in relation to:

• NAD+ biosynthesis pathways

• Mitochondrial efficiency and energy homeostasis

• Cellular methylation dynamics

• Epigenetic regulatory mechanisms

• Metabolic adaptation and signaling networks

5-Amino-1MQ has been examined in research settings as a selective NNMT inhibitor, allowing investigators to explore how modulation of this enzyme affects cellular metabolism and energy regulation under controlled experimental conditions.

Due to its defined chemical structure and stability, 5-Amino-1MQ is well-suited for in vitro and preclinical metabolic research models.

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Common Research Applications

• Investigating NNMT inhibition mechanisms

• Studying NAD+ metabolism and regulation

• Exploring mitochondrial function and energy signaling

• Examining methylation-dependent cellular processes

• Evaluating metabolic adaptation pathways

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Product Specifications

Form: Research-grade small molecule compound

Size:

• 50 mg

Chemical Formula:

• C₁₀H₁₁N₂⁺

Molar Mass:

• 159.21 g/mol

CAS Number:

• 42464-96-0

PubChem CID:

• 950107

Synonyms:

• 5-amino-1-methylquinolinium

• SCHEMBL6403148

• CHEMBL4116828

• ZINC552049

• STL196667

Shelf Life:

• 36 months (when stored under recommended conditions)

Storage:

• Store in a cool, dry place protected from light

Intended Use:

• For laboratory research use only