Kisspeptin-10

Kisspeptin – Research Use Only

Overview

Kisspeptin is a naturally occurring peptide belonging to the RFamide family and is encoded by the KISS1 gene. It is synthesized as a larger precursor protein that is enzymatically cleaved into shorter biologically active fragments, including kisspeptin-54, -14, -13, and -10. These peptides share a conserved C-terminal Arg-Phe-NH₂ (RFamide) motif, which is essential for receptor binding and biological activity.

In laboratory research, kisspeptin is widely studied as a ligand for the G protein-coupled receptor GPR54 (also known as KISS1R), with particular interest in endocrine and neuroregulatory signaling pathways.

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Background

Kisspeptin plays a central role in regulating the hypothalamic-pituitary-gonadal (HPG) axis. In research settings, it is examined for its involvement in:

• Gonadotropin-releasing hormone (GnRH) signaling pathways

• Initiation of puberty and reproductive axis activation

• Hypothalamic neuroendocrine communication

• Placental biology and trophoblast signaling

• Tumor metastasis suppression mechanisms

The peptide’s interaction with the KISS1R receptor has made it a significant focus in endocrine research models exploring reproductive biology, hormone feedback regulation, and cellular signaling dynamics.

Due to its structural versatility and biological importance, kisspeptin remains a key compound in molecular and endocrine pathway investigations.

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Common Research Applications

• Studying hypothalamic-pituitary-gonadal axis regulation

• Investigating GnRH release mechanisms

• Exploring neuroendocrine signaling pathways

• Examining reproductive hormone feedback models

• Evaluating metastasis-related cellular signaling mechanisms

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Product Specifications

Form: Lyophilized peptide (research formulation)

Contents: Kisspeptin

Size:

• 10 mg

Total Active Ingredient:

• 10 mg per 1 vial

Chemical Formula:

• C₂₅₈H₄₀₁N₇₉O₇₈

Molar Mass:

• 5857 g/mol

CAS Number:

• 388138-21-4

PubChem CID:

• 71306396

Synonyms:

• KISS-1 (68-121)

• Protein KISS-1

• Gene KISS1 protein

Shelf Life:

• 36 months (when stored under recommended conditions)

Storage:

• –20 °C recommended for long-term storage

Reconstitution:

• Sterile water (research-grade only)

Intended Use:

• For laboratory research use only