LL-37

LL-37 – Research Use Only

Overview

LL-37 is a human cathelicidin antimicrobial peptide composed of 37 amino acids, derived from the C-terminal portion of the precursor protein hCAP18. It is widely studied in laboratory research for its role in innate immune defense, inflammatory modulation, and tissue repair mechanisms.

LL-37 exhibits broad-spectrum antimicrobial activity in vitro and is commonly examined for its involvement in immune cell signaling, epithelial barrier regulation, and host-defense pathway interactions.

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Background

LL-37 is the only human member of the cathelicidin family of antimicrobial peptides. It is generated through proteolytic cleavage of the precursor protein hCAP18 and plays a significant role in innate immune responses.

In research environments, LL-37 is studied for its involvement in:

• Antimicrobial activity against bacterial, viral, and fungal models

• Regulation of immune cell chemotaxis

• Cytokine signaling and inflammatory modulation

• Epithelial barrier defense mechanisms

• Angiogenesis and tissue remodeling pathways

• Cell proliferation and wound-healing models

Due to its multifunctional nature, LL-37 is frequently utilized in in vitro and preclinical research examining host defense, inflammatory signaling, and tissue repair dynamics.

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Common Research Applications

• Studying innate immune signaling pathways

• Investigating antimicrobial peptide activity

• Exploring inflammatory response modulation

• Examining epithelial barrier regulation

• Evaluating angiogenesis and tissue repair mechanisms

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Product Specifications

Form: Lyophilized peptide (research formulation)

Contents: LL-37 (Human cathelicidin peptide)

Size:

• 5 mg

Chemical Formula:

• C₂₀₅H₃₄₀N₆₀O₅₃

Molar Mass:

• 4493 g/mol

CAS Number:

• 154947-66-7

PubChem CID:

• 16198951

Synonyms:

• Cathelicidin

• Ropocamptide

• Bac4

• Cathelicidin antimicrobial peptide 18 (hCAP18-derived peptide)

Shelf Life:

• 36 months (when stored under recommended conditions)

Storage:

• –20 °C recommended for long-term storage

Reconstitution:

• Sterile water (research-grade only)

Intended Use:

• For laboratory research use only