Melanotan II (MT-2)

Melanotan II (MT-2) – Research Use Only

Overview

Melanotan II (MT-2) is a synthetic peptide modeled after the body’s natural alpha-melanocyte-stimulating hormone (α-MSH). It is commonly used in research to study melanocortin receptors, which play roles in pigmentation, energy balance, and certain neuroendocrine responses. Because of these effects, MT-2 is a key compound in studies involving melanin production and metabolic signaling.

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Background

Melanotan II is a small, stable cyclic peptide that interacts mainly with the MC1R and MC4R receptors. These receptors help regulate:

• Skin pigmentation

• Appetite and energy use

• Neuroendocrine and behavioral responses

By mimicking natural α-MSH activity, MT-2 allows researchers to explore how these pathways function under controlled experimental conditions. Its strong receptor activity and stability make it a useful tool for studying GPCR (G-protein–coupled receptor) signaling.

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Common Research Uses

• Studying melanocortin receptor activation

• Exploring melanin production and pigmentation pathways

• Investigating metabolic and appetite-related signaling in preclinical models

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Product Specifications

• Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH₂

• Molecular Formula: C₅₀H₆₉N₁₅O₉

• Form: Lyophilized powder

• Purity: ≥ 99% (HPLC)

• Storage: –20 °C (long-term)

• Solubility: Sterile water or acetic acid (research-grade only)